Thalprzewalskiinone, a new oxobenzylisoquinoline alkaloid from thalictrum przewalskii

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J Nat Prod. 1999 Jan;62(1):146-8.

Al-Rehaily AJ, Sharaf MHM, Zemaitis MA, Gao Cy, Martin GE, Hadden CE, Thamann TJ, Lin Ft, Schiff PL Jr.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, Department of Spectral Analysis, Beijing Medical University, Beijing, 100083, China, Pharmaceutical Development, Pharmacia &


A novel oxobenzylisoquinoline alkaloid, thalprzewalskiinone (1), was isolated from the roots of Thalictrum przewalskii, and its structure was established via spectroscopic analysis. Five other alkaloids were isolated: the protoberberines pseudocoptisine and berberine, the aporphines (+)-N-methylnantenine and (+)-magnoflorine, and the simple isoquinolone N-methyl-6,7-dimethoxyisoquinolone. Isovanillin was also isolated from this extract.