Thalibealine, a novel tetrahydroprotoberberine–aporphine dimeric alkaloid from Thalictrum wangii

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J Nat Prod. 2001 Jun;64(6):819-22.

Al-Howiriny TA, Zemaitis MA, Gao CY, Hadden CE, Martin GE, Lin FT, Schiff PL Jr.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.


A novel tetrahydroprotoberberine-aporphine dimeric alkaloid, (-)-thalibealine (1), was isolated from the roots of Thalictrum wangiii, and its structure established via spectroscopic analysis. Three other alkaloids were isolated, including the benzyltetrahydroisoquinoline-aporphine dimer (+)-thalmelatidine, the aporphine (+)-magnoflorine, and the protoberberine berberine. This is the first reported isolation of a tetrahydroprotoberberine-aporphine dimer from nature, as well as the first reported isolation of constituents from Thalictrum wangii.