Habitat-dependent variations in berberine content of Berberis asiatica Roxb. ex. DC. in Kumaon, Western Himalaya

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Chem Biodivers. 2010 Feb;7(2):415-20.

Andola HC, Gaira KS, Rawal RS, Rawat MS, Bhatt ID.

G. B. Pant Institute of Himalayan Environment and Development, Kosi-Katarmal, Almora 263 643, Uttarakhand, India.


The variation of the berberine content in roots and stem bark of Berberis asiatica with altitude and edaphic conditions in the western Himalaya was estimated by HPLC. The comparative assessment revealed a significantly higher berberine content in roots than in stem barks. Moreover, the berberine content varied significantly with altitude and edaphic conditions both in root and stem bark samples. The populations growing at low altitude contained significantly more berberine than the ones growing at high altitude. Also the moisture and potassium (K) percentage of the soil significantly influenced the berberine content.