Antinociceptive activity of discretamine isolated from Duguetia moricandiana

Posted by on Nov 28, 2012 in Uncategorized | No Comments

Nat Prod Res. 2011 Dec;25(20):1908-15. Epub 2011 Jul 14.

Almeida JR, de Lima JT, de Oliveira HR, de Oliveira MR, Meira PR, Lúcio AS, Barbosa Filho JM, Quintans Júnior LJ.

Núcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205, Petrolina, Pernambuco, Brazil.


The phytochemical study of Duguetia moricandiana Mart. (Annonaceae) yielded the isolation of the alkaloid which was identified by spectral analysis as discretamine. The evaluation of antinociceptive activity carried out by the acetic acid-induced writhing, formalin and hot plate tests in mice, suggests a potent antinociceptive effect. Discretamine (5, 10 and 20 mg kg⁻¹, i.p.) significantly reduced the number of writhes similarly at all doses tested and the number of paw licks during the first phase of formalin test when compared to control. The effect of discretamine on hot plate response provides a confirmation of its central effect. These results indicate antinociceptive properties of this alkaloid.